NALCN and Global developmental delay: Constitutional variants in the FLNB, LMNA, and NALCN genes have previously been associated with autosomal dominant (AD) disorders, such as Larsen syndrome, Laminopathies, Familial partial lipodystrophy, and Congenital contractures of the limbs, face, hypotonia, and developmental delay, which present clinically with scoliosis or other skeletal abnormalities (29–32).