Seven of the novel loci harbor genes previously associated with hypertension traits such as NPPA, NPR3, PLCE1, TNS2, FURIN, RGL3, and PREX1. Additionally, risk loci were identified near genes involved in placental development (PGR, TRPC6, ACTN4, PZP), uterine spiral artery remodeling (NPPA, NPPB, NPR3, ACTN4), renal function (PLCE1, TNS2, ACTN4, TRPC6), and serum proteostasis maintenance during pregnancy (PZP) (96). This evidence concerns the gene ACTN4 and hypertensive disorder.