Overexpression of USP7 correlates withworse survival of patients with multiple types of cancer, includingmultiple myeloma, and has been shown to contribute to chemoresistance.Here, we represent a structure-based drug repurposing pipeline toidentify novel USP7 inhibitors from a curated library of 6654 FDA-approvedand investigational small molecules. The gene discussed is USP7; the disease is cancer.