frequent mutationsin the ARID1A (44%), SMARCA4 (17%), MLL2(44%), MLL3 (67%), SETD2 (17%), and TET2 (50%) genes associated withhistone modification and chromatin remodeling were identified in individualswith undifferentiated carcinoma with clear cell features. The gene discussed is SETD2; the disease is undifferentiated carcinoma.