The disturbance expression of lncRNAs, linked withthe disordersof gut microbes and mucosal homeostasis, shows a strong associationwith the severity and outcome of UC. lnc-ITSN1-2gene is demonstrated as a strong predictive value for the risk ofinflammatory bowel disease (IBD), particularly in cases of activedisease, and exhibited positive correlations with disease activityand inflammation markers in IBD patients. This evidence concerns the gene ITSN1 and inflammatory bowel disease.