This process concurrently suppresses proinflammatoryresponses, thereby mitigating inflammation. Another research claimed that the dysregulated expression of IL-17is regulated by UBC9 promoter hypermethylation. Xu et al. reported DNA hypomethylation of ZBTB7B promotesthe production of inflammatory cytokines and exacerbates colonic inflammationin UC, by activating the maturation of CD4+ T cells andrepressing the differentiation of CD4+CD8+ Tcells. A comprehensive genome-wide DNAmethylation analysis was conducted on CD4+ T cells associatedwith IBD. This evidence concerns the gene CD8A and irritable bowel syndrome.