The disturbance expression of lncRNAs, linked withthe disordersof gut microbes and mucosal homeostasis, shows a strong associationwith the severity and outcome of UC. lnc-ITSN1-2gene is demonstrated as a strong predictive value for the risk ofinflammatory bowel disease (IBD), particularly in cases of activedisease, and exhibited positive correlations with disease activityand inflammation markers in IBD patients. The gene discussed is ITSN1; the disease is irritable bowel syndrome.