CXCR4 and neoplasm: Furthermore, our data indicate that although CXCR4 co-localizes with diverse vascular structures in the stroma of the orthotopic OSCC mouse model, the inhibition of CXCR4 selectively affects the active angiogenic marker CD105+ endothelial cells in the poorly differentiated tumor stroma and diminishes the maturation of CD105+ vessels, ultimately resulting in tumor necrosis.