To investigate the specific mechanisms underlying the influence of MIF on the development of driver gene-negative lung adenocarcinoma, differential expression analysis was carried out based on MIF expression levels in patients, leading to the identification of 906 differentially expressed genes, with the top 50 genes shown in Figure 4D. Additionally, 294 co-expressed genes of MIF were identified in the tumor tissues of driver gene-negative lung adenocarcinoma, and genes with high correlation were utilized to construct a co-expression network (Figure 4E). This evidence concerns the gene MIF and neoplasm.