To further confirm the relevance of in vitro DUSP6 knockdown results (Figure 4D, 4E), we inoculated DUSP6-knockdown or vector control OCT4-overexpressing A549 cells into NOD/SCID mice to investigate whether knockdown of DUSP6 expression could attenuate tumor growth and metastasis in A549/OCT4 tumor-bearing mice. Here, POU5F1 is linked to neoplasm.