ISOC1 and neoplasm: We initially performed an analysis of the differential expression of 17 intersection genes between renal cancer and adjacent normal tissues using data from the TCGA-KIRC and GSE61441 cohorts (Figure 4A-B) and the results were all consistent with those obtained from eQTL Mendelian randomization analysis, Notably, ISOC1 was found to be highly expressed in adjacent normal tissues compared to tumor tissues.