We initially performed an analysis of the differential expression of 17 intersection genes between renal cancer and adjacent normal tissues using data from the TCGA-KIRC and GSE61441 cohorts (Figure 4A-B) and the results were all consistent with those obtained from eQTL Mendelian randomization analysis, Notably, ISOC1 was found to be highly expressed in adjacent normal tissues compared to tumor tissues. This evidence concerns the gene ISOC1 and renal carcinoma.