Genetic polymorphisms are strongly associated with CAC, and clinical studies have found that the COX-2 -765G > C polymorphism is associated with a reduced risk of CD in the Netherlands and an elevated risk of CRC in Asians, whereas the COX2 8473 T > C polymorphism interacts with NASID and is able to reduce the risk of CRC 94-97. Here, PTGS2 is linked to colorectal carcinoma.