PTH and parathyroid gland adenoma: PHPT is characterized by autonomous secretion of parathyroid hormone (PTH) by parathyroid tissues, and about 80-85% of cases originate from monoclonal parathyroid adenomas (1), the molecular mechanism of which involves cyclin D1 (CCND1/PRAD1) overexpression and the development of Wnt/β-cyclin.