MEN1 and multiple endocrine neoplasia: aberrant activation of the Wnt/β-linker pathway (2), whereas the genetic etiology is most commonly seen in multiple endocrine neoplasia syndromes (MEN1, MEN2A, MEN4) or parathyroid-jaw tumor syndrome (HPT-JT), which are closely associated with germline mutations in genes such as MEN1 and CDC73 (3, 4).