The rhTSH group demonstrated higher TSH and free thyroxine, and lower prolactin and cortisol; participants of this subgroup had better subjective quality (0.65 ± 0.71 vs 1.22 ± 0.92, p=0.002) and efficiency (0.35 ± 0.74 vs 0.72 ± 0.96, p=0.023), less daytime dysfunction (0.52 ± 0.59 vs 0.87 ± 0.82, p=0.03), and better global PSQI score (4.72 ± 3.32 vs 6.60 ± 3.99, p=0.014), while they also showed lower anxiety/depression scores compared to individuals in the LT4-W group (4.32 ± 4.22 vs 5.62 ± 3.85, p=0.046 and 3.55 ± 3.41 vs 5.86 ± 4.22, p=0.005, respectively). The gene discussed is PRL; the disease is depressive disorder.