Therefore, we searched for ACTH and cortisol impact on the liver, the role of HPA axis in liver disorders, HPA axis dysregulation in liver impairment, hepatic consequences of liver glucocorticosteroid receptor (GR) stimulation and inhibition, and the role of intrahepatic cortisol concentration regulation by 11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and 5β-reductase (5βR) in liver disorders. This evidence concerns the gene POMC and liver disorder.