One area of focus has been that higher levels of basal LH, AMH, estradiol (E2) on gonadotropin-releasing hormone antagonist (GnRH-ant) start day and lower levels of LH on GnRH-ant start day had negative association with outcomes, including number of oocytes retrieved, 2PN, available embryos, incidence of OHSS, chemical pregnancy, clinical pregnancy, abortion and live birth; and the specific thresholds ratio of serum LH on the day of GnRH-ant administration to basal LH levels (hLH/bLH) may predict the success of IVF/ICSI outcomes more reliably (31). Here, PLOD1 is linked to ovarian hyperstimulation syndrome.