Following vaccination with same SUM-101 formulation (150 μg MSP1 FL + 5 μg GLA-SE), malaria-naïve individuals showed robust IgM and IgG responses, peaking one month after the third dose (geometric mean titres of 1595 AU for IgM and 13,578 AU for IgG; mean fold changes from baseline of 67 and 889, respectively). This evidence concerns the gene CD40LG and malaria.