Multivariate logistic regression analysis identified ventricular rate (OR = 1.17, 95% CI: 1.10–1.25, P < 0.001) and NT-proBNP (OR = 1.01, 95% CI: 1.00–1.01, P = 0.04) as independent risk factors for POAF in lung cancer patients. This evidence concerns the gene NPPB and lung carcinoma.