Cardiac function indices showed significantly higher NT-proBNP (283.66 pg/ml vs. 97.84 pg/ml, P < 0.001) and creatinine (Cr, 80.95 μmol/L vs. 62.90 μmol/L, P < 0.001) in POAF patients, reflecting close associations between myocardial overload, renal impairment, and AF occurrence. The gene discussed is NPPB; the disease is atrial fibrillation.