They are predominantly localized in the nucleus but can also be observed in stress granules following oxidative stress exposure.81 TIA1, a well-established stress granule marker, was also affected.81 Overexpression of FUS in high-grade gliomas plays a crucial role in tumor progression and malignancy by influencing multiple regulatory pathways.82,83 Destabilization of FUS-mediated signalization repeatedly led to inhibition of glioblastoma cells migration, invasiveness, drug resistance, and glioma angiogenesis.84,85. This evidence concerns the gene TIA1 and glioblastoma.