As a consequence, EV-recipient cells undergo several splicing alterations and acquire a malignant, resistant phenotype.142 Other significantly augmented proteins were canonical histones H3, which were previously found elevated in high-grade glioblastomas and stress-induced EVs.143 Interestingly, NDM downregulated histone demethylase KDMA5, which is considered treatment resistance inducer.144 This trend was followed by NDs but did not reach the threshold cutoff. This evidence concerns the gene H3C1 and glioblastoma.