Moreover, in vitro studies demonstrated that RPL39 knockdown reduced glioblastoma cell proliferation, migration, and colony formation while inhibiting M2 macrophage infiltration.104 Similarly, knockdown of RPL36A in oral cavity squamous cell carcinoma enhanced cell sensitivity to DNA damage and radiation-induced apoptosis.105 Despite these findings, the ribosomal machinery exhibits extreme heterogeneity across tissues, making the precise role of RPL proteins in glioblastoma signaling pathways yet to be fully resolved. This evidence concerns the gene RPL36A and oral cavity squamous cell carcinoma.