Taheri et al revealed that exogenous TIMP3 had no impact on the proliferation of T98G cells but significantly reduced their migration rate.151 Wen et al achieved successful MMP2 depletion, decreased tumor volume, and prolonged survival in mice with U87MG-induced glioblastoma using a bacterial vector for controlled TIMP2 expression.152 In summary, the upregulation of TIMP2 and TIMP3 could serve as an additional anti-migratory factor. This evidence concerns the gene TIMP2 and neoplasm.