Their deregulation can induce secondary transcriptomic changes, impacting cell growth, responsiveness to external stimuli, and positioning specific RPLs as either tumor suppressors or oncogenes.103 One of the key correlations between glioblastoma prognosis and RPL involved RPL39, which has been identified as a prognostic factor due to its overexpression in glioma patients and cell lines. Here, RPL39 is linked to glioma.