CCN1 and glioblastoma: CCN1 is linked with more invasive phenotype in many tumors, including glioblastoma, while reports involving CNN2 indicate that CNN2 function may be cell-type specific.116 A noteworthy study conducted by Lee et al on T98G glioblastoma cells demonstrated that knockdown of the tumor suppressor neurofibromatosis 2 (NF2) led to an upregulation of both CNN proteins.