CCDC80 and thyroid gland carcinoma: Although their role in glioblastoma remains unresolved, research on colorectal and thyroid cancer cells suggests that CCDC80 acts as a tumor suppressor by inhibiting anchorage-independent growth and malignant characteristics.113,114 It was also connected with WNT/β-catenin pathway.115 CCN family members appear to have more diverged roles.