IGHE and Increased total eosinophil count: Based on current evidence, the most promising candidates may be those with early-onset atopy, elevated baseline T2 markers (high total/specific IgE, eosinophilia, elevated FeNO), and clearly dominant sensitization to a single clinically relevant allergen (monosensitization or a strongly dominant allergen is preferable to broad polysensitization) (1, 2, 9).