While controlling for ELISA IL-6 levels, fibrinogen (b = 1.520, p = .210) and its interaction terms fibrinogen × social support (b = −0.060, p = .002), and fibrinogen × social strain (b = 0.054, p < .001) significantly predicted future MDD symptoms, while CRP (b = −1.314, p = .072), CRP × social support (b = 0.031, p = .147), and CRP × social strain (b = −0.003, p = .845) did not significantly predict future MDD symptoms. This evidence concerns the gene CRP and major depressive disorder.