We hypothesize that the exercise group, compared with the attention control group, will exhibit the following: (1) a lower proportion of frail and pre-frail scores and improved individual scores of each frailty component; (2) improvements in systemic inflammatory biomarkers; (3) improved sarcopenia status; (4) increased gene and protein expression of muscle biopsy-driven anti-inflammatory myokines and insulin pathways; and (5) suppressed biochemical progression of PCa. The gene discussed is INS; the disease is sarcopenia.