Thus, we will investigate systemic inflammatory biomarkers associated with frailty [IL-6, TNF-α, C-reactive protein (CRP)] and muscle tissue-related outcomes associated with sarcopenia (myokine release and activation of insulin pathway-related biomarkers) to aid in refining explanations surrounding the frailty–sarcopenia–ADT axis with exercise (5, 24–29). This evidence concerns the gene INS and sarcopenia.