Their work in pancreatic ductal adenocarcinoma (PDAC) also revealed that H3K18la enrichment at promoter regions enhances the transcription of TTK protein kinase (TTK) and BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B), which upregulates the histone acetyltransferase p300 and subsequently enhances glycolytic upregulation (Li et al., 2024a). This evidence concerns the gene TTK and pancreatic ductal adenocarcinoma.