Changes in SQOR expression affect BAX/BCL-2 balance, energy metabolism, and oxidative stress in osteonecrosis/osteoporosis; in male reproduction, ASB1-mediated ubiquitination maintains SQOR stability—ASB1 loss causes SQOR accumulation and H2S depletion, leading to sperm defects. The gene discussed is BCL2; the disease is osteonecrosis.