SQOR and osteosarcoma: In hypoxic tumors such as PDAC, Lin et al. observed that high SQOR expression elevates CoQ10H2, enhancing antioxidant capacity and driving tumor growth and drug resistance; conversely, in immune-responsive tumors (e.g., osteosarcoma), Wang et al. found high SQOR strengthens antioxidant defense and immune activation, showing antitumor effects