In metabolic disease contexts, studies have found that supraphysiological doses of coenzyme Q10 (CoQ10) can specifically upregulate SQOR expression and simultaneously inhibit key enzymes (CBS and CSE) in the transsulfuration pathway, thereby reshaping the serine–folate cycle and nucleotide metabolism (González-García et al., 2020). The gene discussed is SQOR; the disease is metabolic disease.