For example, pretreatment of platinum-resistant ovarian cancer, which was characterized with low levels of 5hmC, with hypomethylating DNMT inhibitor resulted in increased 5hmC level and apoptotic signaling, revealed by the cleaved caspase-3 level (Bisht et al., 2022; Tucker et al., 2018). The gene discussed is DNMT1; the disease is ovarian carcinoma.