However, the recovery of platelet counts was limited, in addition, the respiratory distress and pleural effusions showed little change 2 days after starting prednisolone, and hemophagocytosis, low NK cell activity, and high serum soluble IL-2R level were identified on weekday, so we added oral cyclosporine (5 mg/kg/day) based on the HLH-2004 protocol (4). Here, IL2RA is linked to Hemophagocytosis.