A spectrum of human developmental syndromes (such as Cornelia de Lange syndrome, Roberts-SC phocomelia syndrome, Warsaw breakage syndrome, chronic atrial and intestinal dysrhythmia syndrome, CHOPS syndrome, and alpha-thalassemia/impaired intellectual development syndrome), collectively termed “cohesinopathies”, refers to disorders resulting from variants in genes encoding the cohesin complex and its regulators (such as NIPBL, ESCO2, ANKRD11, HDAC8, DDX11, SGO1, AFF4, ATRX and others) (6). This evidence concerns the gene AFF4 and Cognitive impairment-coarse facies-heart defects-obesity-pulmonary involvement-short stature-skeletal dysplasia syndrome.