FMR1 and Cognitive impairment: In Fmr1 knockout mice, GABAergic inhibitory function in the CA1 region of the hippocampus was impaired, as evidenced by reduced amplitude and frequency of eIPSCs, spontaneous IPSCs, and miniature IPSCs, along with significantly decreased expression of α2, β1, and δ GABAA receptor subunits in the hippocampus, which is associated with behavioral and cognitive deficits.