NF1 and Anxiety: While the general population has experienced elevated stress and anxiety, it is important to examine how children and individuals with pre-existing medical conditions are uniquely affected (4).Neurofibromatosis Type 1 (NF1) is a hereditary disorder caused by mutations in the NF1 gene on chromosome 17q11.2, with a reported birth frequency ranging from 1 in 2,500 to 1 in 3,500 (5, 6).