In the Chronic Renal Insufficiency Cohort (CRIC) study, Bansal et al. [24] evaluated 3,483 patients with CKD stages 2-4 and demonstrated that baseline NT-proBNP and high-sensitivity troponin T (hs-TnT) independently predicted incident HF, even after adjustment for traditional risk factors. Here, NPPB is linked to chronic kidney disease.