Among patients with acute HF enrolled in STRONG-HF, high-intensity care (HIC) reduced the risk of 180-day HF readmission or death, regardless of baseline NT-proBNP. GDMT (guideline-directed medical therapy) up-titration early post-discharge, utilizing increased NT-proBNP as guidance to increase diuretic therapy and reduce the GDMT up-titration rate, resulted in the same 180-day outcomes regardless of early post-discharge NT-proBNP change. Here, NPPB is linked to hydrops fetalis.