Comparative NT-proBNP cutoff values for diagnosis or prognosis differ regionally, and current universal cutoffs (e.g., ≥125 pg/mL for chronic HF, >300 pg/mL for acute HF) [82] may require adjustment in the context of atrial fibrillation, obesity, or renal impairment. The gene discussed is NPPB; the disease is atrial fibrillation.