In addition, proinflammatory cytokines (IL-1, IL-6, IL-23, TNF) and the imbalance in T-cell subtypes, such as T helper 17/T regulatory cell, promote hepatic inflammation and induction of fibrosis, leading to the potential development and progression of liver disease (Powell et al, 2021; Crespo et al, 2001). This evidence concerns the gene TNF and liver disorder.