Within the xanthogranuloma family, it has a spectrum of histopathological features and is characterized by the infiltration of tissues by foamy CD68, factor XIIIa, and negative for CD1a and CD207 (langerin) histoiocytes.7 Rosai-Dorfman disease (RDD), Along with juvenile xanthogranuloma (JXG), ALK-positive histiocytosis (APH), and histiocytic sarcoma (HS), it belongs to the histiocytic neoplasms in the The 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours.8 The gene discussed is F13A1; the disease is sinus histiocytosis with massive lymphadenopathy.