IRF4 and bacterial infectious disease: Additionally, 3 cases of severe viral infection predisposition were linked to a POLR3A, IFIH1, and TLR7XL variation, 3 cases of bacterial infection predisposition were linked to an IRF4, IFNGR1, and NCSTN variation, 1 case of HSE was linked with a SNORA31 variation, and 1 case was linked to an IRAK4 deficiency.