Both primary and secondary HLH have similar clinical and laboratory findings: persistent fever, abdominal pain, organomegaly especially hepatosplenomegaly, CNS manifestations including isolated CNS HLH and encephalopathy, rashes such as petechiae and purpuras, pancytopenia, significant ferritin and triglyceride elevations, low fibrinogen, elevated soluble interleukin-2 receptor alpha (CD-25), and low natural killer (NK) cell activity [1, 10, 12, 13]. This evidence concerns the gene IL2RA and Hepatosplenomegaly.