PON1 and COVID-19: Saadat (2022) investigated whether common functional polymorphisms of the antioxidant enzyme PON1—Q192R (rs662) and L55M (rs854560)—are associated with global COVID-19 burden. Using prevalence, mortality, and diagnostic testing data from 48 countries (as of 25 November 2020) and adjusting for the Human Development Index and testing rates, the study found that the M55 allele frequency showed a significant positive correlation with both COVID-19 prevalence (partial r = 0.487, p = 0.002) and mortality (partial r = 0.551, p < 0.001), whereas Q192R was not associated (Saadat, 2022).