oxLDL is generated when LDL’s lipid core and apoB are oxidatively modified, yielding pro-inflammatory particles that impair endothelial function; in COVID-19, serum oxLDL and the oxLDL/LDL-C ratio rise stepwise from non-severe to severe/critical illness and correlate with inflammation (e.g., CRP), and oxLDL acts as an independent risk factor for progression to severe disease. Here, CRP is linked to COVID-19.