Similarly, a French cohort study evaluating oxidative biomarkers in hospitalized COVID-19 patients reported that while AOPP levels rose significantly in certain severity stages (notably stages 1 and 3), other biomarkers like thiols decreased, and ischemia-modified albumin (IMA) increased, suggesting a complex OS profile in more severe disease (Ducastel et al., 2021). The gene discussed is ALB; the disease is COVID-19.