Homozygous AA genotype of PON1 rs662 and TT genotype of NOS3 rs2070744 were found to be significantly more frequent among patients with severe COVID-19, indicating a potential genetic predisposition to worse outcomes. In contrast, individuals carrying the heterozygous AG genotype of PON1 and TC genotype of NOS3 showed a significantly higher prevalence in the mild COVID-19 group, suggesting that these genotypes may confer a protective effect against severe disease progression in Russia (Eid et al., 2023)(N/A, N/A, N/A). The gene discussed is NOS3; the disease is COVID-19.