While SOD3 variants have been implicated in lung function and susceptibility to chronic respiratory conditions (e.g., COPD) (Ganguly et al., 2009), and SOD3 is anatomically and functionally relevant to lungs (NCBI, 2024), no studies to date have reported associations between SOD3 SNPs and COVID-19 outcomes. This evidence concerns the gene SOD3 and chronic obstructive pulmonary disease.