The G allele of NFE2L2 rs2364723 was significantly less frequent in severe cases, suggesting a protective effect against severe disease (p = 0.02), whereas the G allele of KEAP1 rs9676881 was more common in moderate cases (p = 0.04), and the T allele of KEAP1 rs34197572 was strongly associated with more aggressive COVID-19 both in severe vs. control (p = 0.001) and severe vs. moderate (p = 0.004) comparisons. Here, NFE2L2 is linked to COVID-19.