Despite Nrf2’s central regulatory role in oxidative stress responses, the rs6721961 promoter SNP did not significantly influence COVID-19 risk or disease biomarkers. This suggests that reduced Nrf2 transcriptional activity alone may not critically affect the host response to SARS-CoV-2 infection (Markovic et al., 2023)(Serbia, 265, 265, N/A). This evidence concerns the gene NFE2L2 and COVID-19.