To determine whether SATI gain is an independent protective factor for DFS, we performed a multivariate Cox regression analysis, including common factors associated with DFS such as tumor size, clinical TNM stage, ypTNM stage, lymph node metastasis, presence of tumor deposits, LVI, PNI, and CEA levels, in addition to SATI gain. The gene discussed is ST3GAL5; the disease is neoplasm.