Our investigation delved into the molecular underpinnings of how erinacine S elicits apoptosis through the PAK/FAK/p300 pathway, ultimately mediating epigenetic histone H3K9K14ac of TRAIL, TNFR1, and DR5 in chemoresistant CRC cells, specifically HCT-116/FUR (Fig. 10). This evidence concerns the gene TNFRSF1A and colorectal carcinoma.