POU5F1 and colorectal carcinoma: Moreover, HCT-116/FUR cells displayed a substantially greater expression of Octamer-binding transcription factor 4 (Oct-4) and SRY (sex determining region Y)-box 2 (SOX-2), which are markers associated with putative CSC-like cells 7,8, compared to the parental HCT-116 human CRC cells (Fig. 2B).