Notably, triptolide has been reported to restore chemosensitivity through upregulation of wild-type p53 and inhibition of nuclear factor kappa B (NF-κB) signaling 16, which controls the inflammation, immunity, growth, survival, proliferation, defense against apoptosis, and anti-apoptotic proteins from Bcl-2 families in normal and tumor cells 17. Here, NFKB1 is linked to neoplasm.