These studies have reported therelationship of thyroid hormones to MetS and its related components [16, 45, 46, 47].In previous studies conducted in drug-naïve BD patients, TT4 levelswere not significantly different from those in the healthy controls [48, 49].However, several studies have reported a decrease in TT4 levels in BDpatients treated with mood stabilizers or antidepressants [50, 51, 52]. This evidence concerns the gene TG and metabolic syndrome.