Early research concentrated on topics such as cardiovascular risk (cluster 3), theca-interstitial cells (cluster 7), children (cluster 8), retinol-binding protein 4 (cluster 9), atherogenesis (cluster 10), adipocytokines (cluster 11), atherosclerosis (cluster 13), and IR (cluster 14). The gene discussed is RBP4; the disease is atherosclerosis.