CDK1 and pancreatic ductal adenocarcinoma: For instance, CDK1 downregulation in predicted-sensitive cells aligns with reports associating high CDK1 expression with poor prognosis and GEM resistance [92], [93], while depletion of H2AFZ isoforms has been observed to sensitize pancreatic ductal adenocarcinoma cells to GEM, and to reduce tumor size in a mouse xenograft model [94].