Cardiac collagen deposition in rats may be regulated by RAS activity [57], andthis accumulation can be prevented by non-hypotensive doses of ACE inhibitors.Candy and coworkers [21] asserted that the D allele is associated withworsening of left ventricular (LV) systolic function as well as an increase inleft ventricular cavity size that occurs in idiopathic DCM. This evidence concerns the gene ACE and familial dilated cardiomyopathy.