Research on lung tissues infected with SAR-CoV-2 has revealed a cascade reactionof NLRP3/IL-1β/IL-6 in patients with coronavirus disease 2019 (COVID-19).The secretion of IL-1β related to NLRP3 inflammasome-mediated pyroptosiscan promote the release of IL-6 by leukocytes, exacerbating the condition ofCOVID-19 [91]. The gene discussed is IL6; the disease is COVID-19.