Extra-cardiac manifestations may also serve as early indicators of amyloidosis.A history of bilateral carpal tunnel syndrome, lumbar spinal stenosis, orspontaneous biceps tendon rupture, particularly in elderly individuals, shouldprompt evaluation for transthyretin amyloidosis, especially when cardiac symptomsemerge later in the disease course [106, 107]. The gene discussed is TTR; the disease is amyloidosis.