IRF3 and myocardial infarction: H-151 (STING covalent inhibitor): In the myocardial infarction (MI)model (non-diabetic cardiomyopathy model), by specifically inhibiting thecGAS-STING-IRF3 pathway in infiltrating macrophages, itsignificantly reduced the type I interferon response, thereby: improvingmyocardial contractile function, and reducing cardiac fibrosis [76].