GLMD drives multi-organ cardiovascular injury—encompassing ASCVD, DbCM, HF,and CAN—through interconnected molecular cascades: Vascular inflammation viaAGEs-RAGE/NF-κB axis and lipoprotein dysfunction (e.g., Lp(a)-mediatedthrombosis, HDL impairment). This evidence concerns the gene NFKB1 and Crouzon syndrome-acanthosis nigricans syndrome.