LPA and coronary artery disorder: Two large mendelianrandomization studies have demonstrated that polymorphic variants of theLPA gene (e.g., rs3798220 andrs10455872) are directly strongly linked to increased Lp(a)levels and a higher risk of CHD, providing genetic support for the causalrelationship between Lp(a) and CHD pathogenesis, suggesting that SNPs inthe LPA gene play a crucial role in the formation of HRPs [11, 16].