In the principal analysis, MR analysis using the IVWmethod indicated that each one SD increase in genetically predicted Lp(a) levelswas associated with a 23.7% increased risk of CAD (OR = 1.237, 95% CI:1.173–1.303, p < 0.001), a 3.0% increased risk of AF (OR = 1.030,95% CI: 1.011–1.050, p < 0.001), a 7.4% increased risk of HF (OR =1.074, 95% CI: 1.053–1.096, p < 0.001), a 0.6% increased risk ofhypertension (OR = 1.006, 95% CI: 1.004–1.008, p < 0.001), and a0.1% increased risk of peripheral artery disease (OR = 1.001, 95% CI:1.001–1.001, p < 0.001). Here, LPA is linked to peripheral arterial disease.