In addition to Aβ and tau, the 3xTg-AD model includes an extensive pathology, including gut inflammation (Chen et al., 2021), overly activated hypothalamic-pituitary-adrenal stress axis (Hebda-Bauer et al., 2013), and altered glucose, glutamate, and taurine metabolism (Chiquita et al., 2019; Pfitzer et al., 2025; Sancheti et al., 2014). Here, MAPT is linked to Alzheimer disease.