Figure 5 displays the top 20 COVID-19-associated VDJ patterns for TCRα and TCRβ. In PI subjects, the most frequently used segments were TRAV24/TRAJ42 for TCRα and TRBV6-4/TRBD2/TRBJ2–3 for TCRβ; In HC subjects, the dominant segments were TRAV35/TRAJ42 for TCRα and TRBV7-6/TRBD1/TRBJ2–3 for TCRβ; In RI subjects, the predominant segments were TRAV27/TRAJ42 for TCRα and TRBV6-4/TRBD2/TRBJ2–3 for TCRβ (Figures 5A, B; Supplementary Figure 6). Here, TRBD1 is linked to COVID-19.