Multiple algorithms linked HOXA5 to immune infiltrates (e.g., CD8+ T cells, Endothelial cells, Fibroblasts) and immune checkpoints (negative: CD274, PDCD1, CTLA4 in KIRC/BLCA; positive: LUSC/LUAD/BRCA) (Figures 6C, D). Here, CD8A is linked to bladder transitional cell carcinoma.