This is consistent with the mechanism of IL-38, which promotes Treg expansion and inhibits the inflammatory response of macrophages (65), suggesting that it may become a new target for immune regulation in sepsis.TGF-β: A multifunctional factor that can induce macrophage polarization to the M2 type, inhibit the proliferation and differentiation of Th1/Th2 cells, promote the apoptosis of immune cells, and lead to immunosuppression (59). The gene discussed is IL1F10; the disease is Sepsis.