As such, we hypothesized that inhaled IL-15 in combination with amputation and standard chemotherapy would enhance endogenous NK function in dogs with primary OSA and translate to effective eradication of micro-metastatic disease, defined as disseminated cancer cells that have spread from the primary tumor at the time of surgery but are undetectable on diagnostic testing, and improved outcomes. The gene discussed is IL15; the disease is obstructive sleep apnea syndrome.